Association with the phenotype

Each bar denotes the {{statistic}} of the metabolite across the phenotype with a significant FDR-corrected test (q<{{q_threshold}}). Hover over the bars to see the p values, q values and test statistics. The downloadable CSV includes all tests (even non-significant ones). All fluxes are log-transformed and standardized so statistics are roughly comparable.

Download association test results as CSV...


The plot on the left shows a particular metabolite {{direction}} flux by phenotype for significant interactions. Those show individual metabolite associations with the phenotype. Hover over individual points to see the metabolite annotations.
The plot on the right shows the overall cross-validation performance of a regularized linear regression in explaining the phenotype. This uses a LASSO regression with the regularization parameter learned from a 2-fold cross-validation. The predictions themselves are all based on leave-one-out cross-validation. It can be used as an estimate of the global assocaition of the phenotype with the flux state.

Download {{direction}} fluxes as CSV...

Model performance

{% if type == "quantitative" %}

training R2 = {{score[2]}}

cross-validation R2 = {{score[0]}} ± {{score[1]}}

{% else %}

training accuracy = {{score[2]}}

cross-validation accuracy = {{score[0]}} ± {{score[1]}}

{% endif %}