RefSeq Summary: Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC. Small inducible cytokine subfamily B member 11 (SCYB11) is a CXC member of the chemokine superfamily. It induces a chemotactic response in activated T-cells and is the dominant ligand for CXC receptor-3. The gene encoding SCYB11 protein contains 4 exons and at least three polyadenylation signals which might reflect cell-specific regulation of expression. IFN-gamma is a potent inducer of SCYB11 gene transcription.
Proteome Summary: Cytokine B11; CXC chemokine that has chemotactic activity on activated T cells
Locus Type:
gene with protein product, function known or inferred
Product:
small inducible cytokine subfamily B (Cys-X-Cys), member 11 precursor
Alternate Symbols:
IP9, B-R1, H174, IP-9, I-TAC, CXCL11, SCYB9B
Alias:
small inducible cytokine subfamily B (Cys-X-Cys), member 9B