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This is the beginning of a simple schematic depicting the longest mRNA-encoding exon/intron structure of the gene regionupsream of gene picturenon-coding regionexonnon-coding regionexonnon-coding regionexonnon-coding regionexonnon-coding regiondownstream of gene picture
Click to Display mRNA-Genomic Alignments (spanning 2391 bps)
PubMedOnline Mendelian Inheritance in ManUse AceViewNCBI UniGeneNCBI Genome Map ViewerNCBI Molecular Variation Database (dbSNP)NCBI HomoloGeneGenome DatabaseEnsembl Genome ServerUCSC Genome BrowserMammalian Gene Collection
   Homo sapiens Official Gene Symbol and Name (HGNC)
  SCYB11: small inducible cytokine subfamily B (Cys-X-Cys), member 11
 LocusID: 6373
Overview ?
RefSeq Summary: Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC. Small inducible cytokine subfamily B member 11 (SCYB11) is a CXC member of the chemokine superfamily. It induces a chemotactic response in activated T-cells and is the dominant ligand for CXC receptor-3. The gene encoding SCYB11 protein contains 4 exons and at least three polyadenylation signals which might reflect cell-specific regulation of expression. IFN-gamma is a potent inducer of SCYB11 gene transcription.
 
Proteome Summary: Cytokine B11; CXC chemokine that has chemotactic activity on activated T cells
Locus Type: gene with protein product, function known or inferred
Product: small inducible cytokine subfamily B (Cys-X-Cys), member 11 precursor
Alternate Symbols: IP9, B-R1, H174, IP-9, I-TAC, CXCL11, SCYB9B
Alias: small inducible cytokine subfamily B (Cys-X-Cys), member 9B
FunctionSubmit GeneRIF(All Pubs)?
  GeneRIF: Gene References into Function:  
  11559369
  • chemotactic activity for CXCR3-expressing cells; substrate for dipeptidylpeptidase IV

      Gene OntologyTM:  
     Term Evidence Source Pub
     
  • chemokine
  • E Proteome pm
     
  • chemotaxis
  • E Proteome pm
     
  • signal transduction
  • P Proteome pm
     
  • cell-cell signalling
  • E Proteome pm
     
  • inflammatory response
  • P Proteome pm
     
  • response to pathogenic fungi
  • P Proteome pm
      Other Ontologies:  
     Term Evidence Source Pub
     
  • Response to injury
  • NR Proteome pm
     
  • Anti-pathogen response
  • NR Proteome pm
     
  • Cell migration/motility
  • NR Proteome pm
     
  • Cell-to-cell signalling
  • NR Proteome pm

    Relationships ?
      Mouse Homology Maps:     
        NCBI vs. MGD   Scyb11Hs
        UCSC vs. MGD   Scyb11Hs

    Map Information ?
      Chromosome:4   mv
      Cytogenetic:4q21.2  RefSeq 

    NCBI Reference Sequences (RefSeq)?
    Category: REVIEWED
     mRNA: NM_005409    
     Protein: NP_005400  small inducible cytokine subfamily B (Cys-X-Cys), member 11 precursor BL
     Domains: Small cytokines (intecrine/chemokine) score: 76  
       Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). score: 88  
     GenBank Source: AF030514,U66096,Y15220    

    Category: NCBI Genome Annotation
     Genomic Contig: NT_022760   gb sv mv ev mm
      Annotated transcripts/proteins for this locus:
     Evidence: supported by alignment with mRNA   
     Model mRNA: XM_113426    
     Model Protein: XP_113426   BL
     Domains: Small cytokines (intecrine/chemokine), interleukin-8 like score: 87  
       Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). score: 89  

    GenBank Sequences ?
    Nucleotide Type Protein   
    A82120 g CAB69205   BL
    AF053972 g AAD10206   BL
    AF077867 g AAD38327   BL
    Y15221 g CAB51859   BL
    AF002985 m AAC51845   BL
    AF030514 m AAC39775   BL
    BC005292 m AAH05292   BL
    U59286 m AAB17374   BL
    U66096 m AAD38867   BL
    Y15220 m CAA75510   BL

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