RefSeq Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion.
Proteome Summary: Receptor-type protein tyrosine phosphatase M
Locus Type:
gene with protein product, function known or inferred
Product:
protein tyrosine phosphatase, receptor type, M precursor
Alternate Symbols:
RPTPM, RPTPU, PTPRL1, HR-PTPU, R-PTP-MU
Alias:
protein tyrosine phosphatase mu precursor protein tyrosine phosphatase, receptor type, mu polypeptide