InterPro Entry IPR001171

Ergosterol biosynthesis ERG4/ERG24 enzymes

Database InterPro
Accession IPR001171; ERG4_ERG24 (matches 29 proteins)
Name Ergosterol biosynthesis ERG4/ERG24 enzymes
Type Family
Dates 08-OCT-1999 (created)
14-NOV-2000 (last modified)
Signatures PS01017; ERG4_ERG24_1 (16 proteins)
PS01018; ERG4_ERG24_2 (13 proteins)
PF01222; ERG4_ERG24 (29 proteins)
Component membrane (GO:0016020)
Abstract The two fungal enzymes, C-14 sterol reductase (gene ERG24 in budding yeast and erg3 in Neurospora Crassa) and C-24(28) sterol reductase (gene ERG4 in budding yeast and sts1 in fission yeast), are involved in ergosterol biosynthesis. They act by reducing double bonds in precursors of ergosterol [1]. These proteins are highly hydrophobic and seem to contain seven or eight transmembrane regions. Chicken lamin B receptor that is thought to anchor the lamina to the inner nuclear membrane belongs to this family.
Examples
References
  1. Lai M.H., Bard M., Pierson C.A., Alexander J.F., Goebl M., Carter G.T., Kirsch D.R.
    The identification of a gene family in the Saccharomyces cerevisiae ergosterol biosynthesis pathway.
    Gene 140: 41-49(1994).
    [MEDLINE:94171077] [PUB00001844]
Database links PROSITE doc; PDOC00780
Blocks; IPB001171
Matches Table   all   Graphical   all   Condensed graphical view