Locus Link Logo
PubMed Entrez BLAST OMIM Taxonomy Structure
  Search   Display       Organism:
   Query:
white space
View One of 1 Loci
A
B
C
D
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
U
V
W
X
Y
Z

This is the beginning of a simple schematic depicting the longest mRNA-encoding exon/intron structure of the gene regionnon-coding regionexonnon-coding regionexonnon-coding regionexonnon-coding regionexonnon-coding regionexonnon-coding regionexonnon-coding regionexonnon-coding regionexonnon-coding regionexonnon-coding regionexonnon-coding regionexonnon-coding regionexonnon-coding regionexonnon-coding regionexonnon-coding regionexonnon-coding regionexonnon-coding regionexonnon-coding regionexonnon-coding regionexonnon-coding regionexonnon-coding regionexonnon-coding region
Click to Display mRNA-Genomic Alignments (spanning 81484 bps)
PubMedNCBI UniGeneNCBI Genome Map ViewerNCBI HomoloGeneMouse Genome Informatics
   Mus musculus Official Gene Symbol and Name (MGI)
  Kit: kit oncogene
 LocusID: 16590
Overview ?
RefSeq Summary: The c-Kit proto-oncogene is the cellular homolog of the transforming gene of a feline retrovirus (v-Kit). The c-kit protein includes characteristics of a protein kinase transmembrane receptor.
Locus Type: gene with protein product, function known or inferred
Product: c-kit
Alternate Symbols: W, Bs, Fdc, Ssm, CD117, c-KIT, belly-spot
Alias: dominant spotting
spotted sterile male
Steel Factor Receptor
Dominant white spotting
c-kit proto-oncogene protein
FunctionSubmit GeneRIF(All Pubs)?
  GeneRIF: Gene References into Function:  
  11964302
  • Critical roles of c-Kit tyrosine residues 567 and 719 in stem cell factor-induced chemotaxis

      Gene OntologyTM:  
     Term Evidence Source Pub
     
  • membrane
  • IEA MGD  
     
  • ATP binding
  • IEA MGD  
     
  • transferase
  • IEA MGD  
     
  • intracellular
  • IEA MGD  
     
  • protein kinase
  • IEA MGD  
     
  • protein tyrosine kinase
  • IEA MGD  
     
  • regulation of cell cycle
  • IEA MGD  
     
  • integral membrane protein
  • IEA MGD  
     
  • cell growth and/or maintenance
  • IEA MGD  
     
  • protein amino acid phosphorylation
  • IEA MGD  
     
  • transmembrane receptor protein tyrosine kinase
  • IEA MGD  
     
  • transmembrane receptor protein tyrosine kinase signaling pathway
  • IEA MGD  

    Relationships ?
      Human Homology Maps:     
        NCBI vs. MGD 4q11-q12 KITMm Hs
        UCSC vs. MGD 4q11-q12 KITMm Hs
        NCBI vs. EST-based RH Map 4q11-q12 X06182Mm Hs
        UCSC vs. EST-based RH Map 4q11-q12 X06182Mm Hs
        UCSC vs. Hudson et al. 4q11-q12 AW263947Mm Hs

    Map Information ?
      Chromosome:5   mv
      Cytogenetic:5  RefSeq 
      Genetic:5 42.0 cM  MGD 
      Markers: Chr. 53714  
       Chr. 5Y00864  

    NCBI Reference Sequences (RefSeq)?
    Category: REVIEWED
     mRNA: NM_021099    
     Protein: NP_066922  c-kit BL
     Domains: Immunoglobulin score: 125  
       Immunoglobulin domain score: 94  
       Protein kinase domain score: 198  
       Immunoglobulin C-2 Type score: 83  
       Tyrosine kinase, catalytic domain score: 610  
       Serine/Threonine protein kinases, catalytic domain score: 159  
     Strain BALB/c    
     GenBank Source: AW741410,Y00864    

    Category: NCBI Genome Annotation
     Genomic Contig: NW_000230   gb sv mv ev mm
     Strain C57BL/6J    
      Annotated transcripts/proteins for this locus:
     Evidence: supported by alignment with both mRNA and ESTs (51)   
     Model mRNA: XM_132123    
     Model Protein: XP_132123   BL
     Domains: Immunoglobulin score: 125  
       Immunoglobulin domain score: 94  
       Protein kinase domain score: 402  
       Immunoglobulin C-2 Type score: 83  
       Tyrosine kinase, catalytic domain score: 616  
       Serine/Threonine protein kinases, catalytic domain score: 308  

    GenBank Sequences ?
    Nucleotide Type Protein Strain 
    L11358 g AAA37420 BALB/c BL
    X65998 g CAA46799 ICR BL
        CAA46800   BL
    AW741410 m      
    X65997 m CAA46798 ICR BL
    Y00864 m CAA68772 BALB/c BL

    Additional Links ?
     

    To Top

    Questions or Comments?
    Write to the NCBI Service Desk