ENTRY EC 3.5.4.4 NAME Adenosine deaminase CLASS Hydrolases Acting on carbon-nitrogen bonds, other than peptide bonds In cyclic amidines SYSNAME Adenosine aminohydrolase REACTION Adenosine + H2O = Inosine + NH3 SUBSTRATE Adenosine H2O PRODUCT Inosine NH3 INHIBITOR Nebularine 6-Hydroxyl-1,6-dihydropurine ribonucleoside COMMENT Inhibited by Nebularine and 6-hydroxyl-1,6-dihydropurine ribonucleoside (Science (1989) 243, 1591-1593). PATHWAY PATH: MAP00230 Purine metabolism DISEASE MIM: 102700 Adenosine deaminase; Severe combined immunodeficiency due to ADA deficiency (3); Hemolytic anemia due to ADA excess (1) MOTIF PS: PS00485 S-[LIVM]-[NS]-T-D-D-P GENES ECO: ECOLI_1582(add) SCE: YNL141W(N1208) HSA: 119649(ADA) DBLINKS University of Geneva ENZYME DATA BANK: 3.5.4.4 WIT (What Is There) Metabolic Reconstruction: 3.5.4.4 SCOP (Structural Classificaion of Proteins): 3.5.4.4 PDB: 1ADD 1FKW 1FKX 2ADA PIR: DUMSA DUHUA A37943 ///