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This is the beginning of a simple schematic depicting the longest mRNA-encoding exon/intron structure of the gene regionnon-coding regionexonnon-coding regionexonnon-coding regionexonnon-coding regionexonnon-coding regionexonnon-coding regionexonnon-coding regionexonnon-coding regionexonnon-coding regionexonnon-coding regionexonnon-coding regionexonnon-coding regionexonnon-coding regionexonnon-coding regionexonnon-coding region
Click to Display mRNA-Genomic Alignments (spanning 110510 bps)
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   Homo sapiens Official Gene Symbol and Name (HGNC)
  PTPRM: protein tyrosine phosphatase, receptor type, M
 LocusID: 5797
Overview ?
RefSeq Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion.
 
Proteome Summary: Receptor-type protein tyrosine phosphatase M
Locus Type: gene with protein product, function known or inferred
Product: protein tyrosine phosphatase, receptor type, M precursor
Alternate Symbols: RPTPM, RPTPU, PTPRL1, HR-PTPU, R-PTP-MU
Alias: protein tyrosine phosphatase mu precursor
protein tyrosine phosphatase, receptor type, mu polypeptide
FunctionSubmit GeneRIF(All Pubs)?
 EC Number:  3.1.3.48                                                       
      Gene OntologyTM:  
     Term Evidence Source Pub
     
  • protein dephosphorylation
  • E Proteome pm
     
  • integral plasma membrane protein
  • P Proteome pm
     
  • transmembrane receptor protein tyrosine phosphatase
  • E Proteome pm
      Other Ontologies:  
     Term Evidence Source Pub
     
  • Hydrolase
  • E Proteome pm
     
  • Integral membrane
  • P Proteome pm
     
  • Receptor (signalling)
  • P Proteome pm

    Relationships ?
      Mouse Homology Maps:     
        NCBI vs. MGD 17 38.30 cM PtprmHs Mm
        UCSC vs. MGD 17 38.30 cM PtprmHs Mm

    Map Information ?
      Chromosome:18   mv
      Cytogenetic:18p11.2  HUGO 
      Markers: Chr. -G10607  
       Chr. 18WI-9017   mv
       Chr. 18Cda09f01   mv

    NCBI Reference Sequences (RefSeq)?
    Category: REVIEWED
     mRNA: NM_002845    
     Protein: NP_002836  protein tyrosine phosphatase, receptor type, M precursor BL
     Domains: MAM domain score: 406  
       Immunoglobulin score: 102  
       Fibronectin type 3 domain score: 101  
       Fibronectin type III domain score: 126  
       Protein-tyrosine phosphatase score: 800  
       Dual specificity phosphatase, catalytic domain score: 86  
       Dual specificity phosphatase, catalytic domain score: 84  
       Protein tyrosine phosphatase, catalytic domain score: 857  
       Protein tyrosine phosphatase, catalytic domain motif score: 324  
       Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others) score: 436  
     GenBank Source: AA281524,X58288    

    Category: NCBI Genome Annotation
     Genomic Contig: NT_030853   gb sv mv ev mm
      Annotated transcripts/proteins for this locus:
     Evidence: supported by alignment with both mRNA and ESTs (15)   
     Model mRNA: XM_012741    
     Model Protein: XP_012741   BL
     Domains: Protein-tyrosine phosphatase score: 766  
       Dual specificity phosphatase, catalytic domain score: 84  
       Protein tyrosine phosphatase, catalytic domain score: 786  
       Protein tyrosine phosphatase, catalytic domain motif score: 310  

    GenBank Sequences ?
    Nucleotide Type Protein   
    AA281524 m      
    X58288 m CAA41226   BL

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