PROSITE: PDOC00933 (documentation)
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{PDOC00933}
{PS01213; GLOBIN_FAM_2}
{BEGIN}
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* Protozoan/cyanobacterial globins signature *
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Globins are heme-containing proteins involved in binding and/or transporting
oxygen [1]. Almost all globins belong to a large family (see <PDOC00793>), the
only exceptions are the following proteins which form a family of their own
[2,3]:
- Monomeric hemoglobins from the protozoan Paramecium caudatum, Tetrahymena
pyriformis and Tetrahymena thermophila.
- Cyanoglobin from the cyanobacteria Nostoc commune.
- Globins LI637 and LI410 from the chloroplast of the alga Chlamydomonas
eugametos.
- Mycobacterium tuberculosis hypothetical protein MtCY48.23.
These proteins contain a conserved histidine which could be involved in heme-
binding. As a signature pattern, we use a conserved region that ends with this
residue.
-Consensus pattern: F-[LF]-x(5)-G-[PA]-x(4)-G-[KRA]-x-[LIVM]-x(3)-H
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in SWISS-PROT: NONE.
-Last update: November 1997 / First entry.
[ 1] Concise Encyclopedia Biochemistry, Second Edition, Walter de Gruyter,
Berlin New-York (1988).
[ 2] Takagi T.
Curr. Opin. Struct. Biol. 3:413-418(1993).
[ 3] Couture M., Chamberland H., St-Pierre B., Lafontaine J., Guertin M.;
Mol. Gen. Genet. 243:185-197(1994).
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